A Study of Evaluating the Efficacy and Safety of SHR4640 in Subjects With Gout

Inclusion Criteria: 1. Subject who met 1977 or 2015 ACR (American College of Rheumatology) classification of Gout and has a serum acid ≥ 480 μmol/L at screening; 2. 18 kg/m2 ≤Body mass index (BMI)≤ 35 kg/m2 Exclusion Criteria: 1. Subject who is pregnant or breastfeeding; 2. Alanine aminotransferase or Aspartate aminotransferase or total bilirubin\>1.5 upper normal limit; 3. Subject with a positive test for HLA-B\*5801; 4. Estimated glomerular filtration rate (MDRD formula) \<60ml/min; 5. HbA1c\>8%; 6. Subject with known hypersensitivity or allergy to SHR4640 and allopurinal, or any component of SHR4640; 7. Subject with kidney stones or suspicion of kidney stones; 8. Subject who has acute gout flares within 2 weeks before randomization; 9. Subject with a history of malignancy within the previous 5 years; 10. Subject with a history of active peptic ulcer within a year; 11. Subject with a history of xanthine urine.