Effects of Drugs on Responses to Brain and Emotional Processes

Early Phase 1CompletedNCT04053036

University of Chicago22 enrolled

Overview

To study the effects of a psychostimulant on responses to affective touch in individuals with a range of autistic traits

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Autism Spectrum Disorder Healthy

Interventions

MDMADRUG

Participants will be given 1.5mg/kg of MDMA

Placebo oral tabletDRUG

Participants will be given a placebo capsule that will only contain lactose.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 19 and 30 (no one under 130 lbs) * Smokers smoking less than 25 cigarettes per week * Have used ecstasy no more than 40 times with no adverse responses. Exclusion Criteria: * High blood pressure * Any medical condition requiring regular medication * Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis * Individuals with a history of dependence on stimulant drugs. * Women who are pregnant or trying to become pregnant

Locations (1)

University of Chicago

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Change in Responses to Affective Touch

Participants will complete an affective touch task during which time they will rate pleasantness of touch on a scale of -10 to +10 using an analog scale. Higher ratings indicate greater pleasantness.

Time frame: 1.5 hrs after drug or placebo administration.

Data from ClinicalTrials.gov

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