200 pregnant women with symptomatic placenta previa with previous bleeding attacks attending Ain Shams University maternity hospital will be recruited and randomized to receive either tranexamic acid tablets (500mg four times daily) or placebo. Amount of bleeding during antepartum bleeding attacks will be estimated (by hemoglobin change from baseline at admission till delivery).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
200
Pregnant women with symptomatic placenta previa with previous bleeding attacks will receive tranexamic acid tablets (500mg four times daily) till delivery.
Pregnant women with symptomatic placenta previa with previous bleeding attacks will receive placebo tablets four times daily till delivery.
Ain SHams Maternity Hospital
Cairo, Abbaseya, Egypt
RECRUITINGAmount of bleeding during antepartum bleeding attacks
Amount of bleeding during antepartum bleeding attacks will be estimated by hemoglobin change from baseline at admission till delivery.
Time frame: 9 weeks GA
Number of women requiring antepartum blood transfusion
Number of women requiring antepartum blood transfusion for resuscitation after severe antepartum hemorrhage.
Time frame: 9 weeks GA
Number of PRBCs units required during antepartum blood transfusion
Number of PRBCs required during antepartum blood transfusion for resuscitation after severe antepartum hemorrhage.
Time frame: 9 weeks GA
Number of pregnant women experiencing severe antepartum hemorrhage necessitating urgent delivery
Number of pregnant women experiencing severe antepartum hemorrhage necessitating urgent delivery
Time frame: 9 weeks GA
Gestational age at delivery
Gestational age in weeks at the time of delivery
Time frame: 9 weeks GA
Neonatal intensive care unit (NICU) admission
Number of neonates requiring NICU admission.
Time frame: 9 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.