A Trial to Evaluate the Optimal Dose of MV-LASV (V182-001)

Inclusion Criteria: 1. Signed informed consent obtained before any trial-related activities 2. Healthy men or women aged 18 to ≤ 55 years on the day of consenting 3. Ability to comprehend the full nature and purpose of the study, including possible risks and side effects; ability to cooperate with the investigator and to comply with the requirements of the entire study 4. All female participants of childbearing potential, defined as all woman physiologically capable of becoming pregnant, must have a negative pregnancy test at screening 5. Willingness not to become pregnant or to father a child during the study up to 182 days after the first vaccination by practicing reliable methods of contraception 6. Availability during the duration of the trial Exclusion Criteria: 1. Participation in another investigational clinical study (including exposure to an IMP or device) within four weeks before the screening visit or planned concurrent participation in another clinical study before study completion 2. History of immunodeficiency, known HIV infection or current hepatitis B/C infection 3. History of drug addiction including alcohol dependence within the last two years 4. Inability or unwillingness to avoid intake of more than around 20g alcohol per day during 48 hours after each vaccination 5. Vaccination within four weeks prior to first vaccination or planning to receive any non-study vaccine within 182 days after the first vaccination 6. Prior receipt of any Lassa vaccine 7. Recent infection within one week prior to Screening visit 8. Blood donations including plasma donations, 90 days prior to Screening visit and anticipated blood, plasma, tissue, sperm or organ donation, throughout the study until end of treatment period 9. Clinically relevant history of renal, hepatic, gastrointestinal, cardiovascular, respiratory, skin, hematological, endocrine, inflammatory, autoimmune or neurological diseases or clinically relevant abnormal laboratory values, that in the opinion of the investigator may interfere with the aim of the study 10. History of neoplastic disease (excluding non-melanoma skin cancer that was successfully treated) within the past five years or a history of any hematological malignancy 11. Behavioral, cognitive, or psychiatric condition that in the opinion of the investigator affects the ability of the participant to understand and cooperate with the study protocol 12. History of severe adverse reactions to vaccine administration, including anaphylaxis and related symptoms, such as urticaria, respiratory difficulty, angioedema and abdominal pain to vaccines, or history of allergic reaction likely to be exacerbated by any component of the vaccine 13. History of or present hearing deficit 14. Present thrombocytopenia and/or history of thrombocytopenia and/or bleeding disorders. 15. History of anaphylaxis to drugs or other allergic reactions, which the investigator considers compromising the safety of the volunteer 16. Use of medication during two weeks before the first vaccination and throughout the study, which the investigator considers affecting the validity of the study, except hormonal contraception or hormonal replacement therapy in female participants (prior to taking any medication within 72 hours before study vaccination, the participant should consult the investigator) 17. Use of immunosuppressive drugs like corticosteroids (excluding topical preparations) within 30 days prior to the first vaccination or anticipated use before completion of day 182 18. Receipt of blood products or immunoglobulins within 120 days prior to the Screening Visit or anticipated receipt of any blood product or immunoglobulin before completion of day 182 19. Pregnancy or lactation at screening or planning to become pregnant before completion of day 182 20. Unreliable contraception Methods 21. Persons in a direct relationship with the sponsor, an investigator or other study team members. Direct dependent relationships include close relatives (i.e. children, parents, partner/spouse, siblings) as well as employees of the clinical study site or the sponsor 22. Individuals who are living and/or working with severely immunocompromised people, children under 15 months old or pregnant women 23. Participants who travelled within one year prior to the first vaccination or plan to travel during the study to an endemic country 24. A rash, dermatological condition or tattoos that would, in the opinion of the Investigator, interfere with injection site reaction rating