Sepsis at Södersjukhuset-Adherence to Treatment Guidelines

Karolinska Institutet11,000 enrolled

Overview

A retrospective single-center study with patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. The aim is to describe the association between adherence to treatment guidelines, gender, incidence and mortality for patients with sepsis.

In this single-center study, patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years will be included. About 11,000 patients will be included. Patient data including described sepsis symptoms will be drawn from the electronic medical record, TakeCare and Clinisoft. Logistic regression analysis will adjust for age, gender, comorbidity according to Charlson score, vital signs, with preliminary focus of infection (pneumonia, urinary tract infection, abdominal, other, unknown). The Surviving Sepsis guidelines for the time period are: 3-hour bundle including lactate measurement, obtaining blood culture, fluid treatment if hypotensive and administration of broad-spectrum antibiotics. The 6-hour bundles with administration of vasopressors if needed, remeasure lactate if elevated, with persistent hypotension re-asses volume status and tissue perfusion. Time zero is defined as the admission time to the emergency department. The aim is to describe the association between adherence to treatment guidelines, gender, incidence and mortality for patients with sepsis.

Study Type

OBSERVATIONAL

Enrollment

11,000

Conditions

Sepsis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: • Patients admitted to the Emergency Department at Södersjukhuset with suspicion of sepsis defined as blood cultures taken and intravenous antibiotics of type beta-lactam or aminoglycoside prescribed within 48 hours of admission. Exclusion criteria: • Patients transferred from other hospitals or treatment clinics.

Locations (1)

Södersjukhuset

Stockholm, Sweden

Outcomes

Primary Outcomes

Gender differences in 90-day mortality

Gender differences in percentage of patients who died before day 90

Time frame: 90 days

Secondary Outcomes

Association between adherence to treatment guidelines and mortality

Association between number of completed sepsis bundles and mortality

Time frame: 90 days

Incidence of sepsis

Number of patients admitted to the Emergency Department at Södersjukhuset during the study period comparing to the hospitals catchment area

Time frame: 90 days

Data from ClinicalTrials.gov

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