Structural and Functional Changes in Neuronal Intranuclear Inclusion Disease(NIID)

N/AUnknownNCT04055857

First Affiliated Hospital of Zhejiang University30 enrolled

Overview

To discover the microstructure, macrostructure and functional changes with 7T multi-modal magnetic resonance imaging of Neuronal Intranuclear Inclusion Disease, and to explore new biomarkers for evaluating the severity and the progression of Neuronal Intranuclear Inclusion Disease.

Study Type

OBSERVATIONAL

Enrollment

30

Conditions

Neuronal Intranuclear Inclusion Disease

Interventions

OTHER

There is no Intervention.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients diagnosed with NIID 2. Older than 18 years; 3. Sign the informed consent form. Exclusion Criteria: 1. The informed consent is withdrawn by the subject; 2. Contraindications or intolerance to MRI: metallic foreign bodies, instability of vital signs, epilepsy, claustrophobia, etc.

Locations (1)

Siemens 7T MR

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

fractional anisotropy (FA)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: baseline

mean diffusivity (MD)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: baseline

Intracellular volume fraction(icvf)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: baseline

orientation dispersion index (ODI)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: baseline

fiber number(fiber pass through the lesions)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: baseline

fractional anisotropy (FA)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: 6 months

mean diffusivity (MD)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: 6 months

Intracellular volume fraction(icvf)

Parameters to describe integrity of white matter in diffusion MR Imaging

Time frame: 6 months

orientation dispersion index (ODI)

Parameters to describe integrity of white matter in diffusion MR Imaging

Central Contacts

Hui Liang, Doctor

CONTACT

18757139736 pushup@zju.edu.cn

Daqiang Ke, Bachelor

CONTACT

15658173819 zhemuzhi@163.com

Data from ClinicalTrials.gov

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NCT04055857 - Structural and Functional Changes in Neuronal Intranuclear Inclusion Disease(NIID) | Crick | Crick