Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants. In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
90
During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds.
Umbilical cord will be milked from th distance of 20cm from mother's side to the baby, for 3-4 times.
Istanbul Kanuni Sultan Suleyman Training and Research Hospital
Istanbul, Turkey (Türkiye)
RECRUITINGConcentration of Stem cells
Determining the quantity of endogenous stem cells transmitted through the umbilical cord to the infant after different types of cord clamping.
Time frame: 6 months
Number of Participants with Neonatal Morbidities
Recording newborn morbidities such as intraventricular hemorrhage , necrotizing enterocolitis, bronchopulmonary dysplasia , retinopathy of prematurity which are detected in the study population.
Time frame: 6 months
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