Non-invasive Modulation of Autonomic Cardiac Nervous System

Overview

To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.

First part: Assessment of the muscle sympathetic nerve activity (MSNA) at baseline using microneurography performed on the superficial peroneal nerve. Second part: Acquisition of the MSNA signal during non-invasive VNS and apnea. Non-invasive VNS is performed using several frequencies of stimulation. Maximal and voluntaries apnea are performed at the end of the expiration. Continuous recording of the following parameters: * non-invasive arterial blood pressure * R-R interval * electrocardiogram * MSNA activity * respiratory curve signal * respiratory rate, oxygen saturation

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Central Contacts