Cardiac surgery saves lives when patients suffer from cardiac disease. Local inflammation is important for tissue repair and wound healing after such an operation. Inflammation starts already when the patient is treated in the intensive care unit. When inflammatory proteins (cytokines) are released into the circulation, they cause also a systemic inflammation, which alerts the immune system of the body and activates defence mechanisms (=adaptive response). In some patients, systemic inflammation is out of control thereby causing organ dysfunctions, shock, and in the most severe cases even death (=maladaptive response). The aim of this study is to investigate the early phase of inflammation after the operation. Repeated blood samples will be taken of patients undergoing cardiac surgery to describe the patterns and dynamics of inflammation proteins. A better understanding of these mechanisms will potentially lead to improved treatment of patients after cardiac surgery.
The aim of this project is to understand early inflammation mechanisms after cardiac surgery. Therefore, repeated blood samples of patients undergoing cardiac surgery will be taken. Patients are selected after "open" cardiac surgery (via sternotomy), when when they require postoperative care in the cardiovascular intensive care unit. The blood samples will be analysed in collaboration with the Inflammation Research Unit of the Department of Internal Medicine at the University Hospital Zurich.
Study Type
OBSERVATIONAL
Enrollment
64
Five Timepoints: baseline (pre-operative), ICU admission, 4 hours after ICU admission, 8 hours after ICU admission, 48 hours after ICU admission
University Hospital
Zurich, Switzerland
Plasma concentration of Wnt5a (ng/ml)
Measured by a commercially available ELISA
Time frame: Up to 48 hours after ICU admission
Plasma concentration of sFRP1 (ng/ml)
Measured by a commercially available ELISA
Time frame: Up to 48 hours after ICU admission
Plasma concentration of sFRP5 (ng/ml)
Measured by a commercially available ELISA
Time frame: Up to 48 hours after ICU admission
Plasma concentration of WIF-1 (pg/ml)
Measured by a commercially available ELISA
Time frame: Up to 48 hours after ICU admission
Daily fluid balance (ml)
Routine parameter taken from charts
Time frame: Up to 48 hours after ICU admission
Occurrence of complications (yes/no): composite endpoint of hemodynamic instability (defined as norepinephrine concentration = or > 0.1mcg/kg/min), delirium (defined as ICDSC score = or > 4), infections
Routine parameter taken from charts
Time frame: Up to 7 days after ICU admission
Length of ICU stay (days)
Routine parameter taken from charts
Time frame: Up to 4 weeks
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