Impact of Peripheral Vascular Stiffness Assessment on Risk Prediction in Patients With Myocardial Infarction

University Hospital, Lille2,000 enrolled

Overview

Risk assessment after myocardial infarction is critical in daily practice and evolution toward heart failure especially diastolic heart failure remains a key issue. All consecutive patients with myocardial infarction (either STEMI or NSTEMI but excluding type 2 MI) presenting at university hospital of Lille within 48 hours after symptom onset will be recruited in the RIGID-MI registry. The RIGID-MI study proposes to deeply evaluate at 1 month after MI: peripheral vascular disease, vascular stiffness, ventriculo-arterial coupling and other usual risk factors. The main objective is to identify clinical, biological and imaging parameters associated with poor prognosis, especially evolution toward diastolic heart failure, recurrence of MI, and bleeding.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Myocardial Infarction Vascular Stiffness Heart Failure

Interventions

Imaging evaluation for vascular assessment

At 1month after MI, Blood sample for total blood, plasma and PBMC collection, ECG, 3D-trans thoracic echocardiography for ventriculo-arterial coupling assessment, Vascular doppler for peripheral artery disease assessment, Arterial stiffness evaluation, Bilateral transcranial doppler for HITS evaluation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Signed informed consent * Affiliated to national health insurance (French social security number) * Presenting with MI within 48 hours of symptom onset Exclusion Criteria: * Patient under curatorship * Type 2 MI * Presenting with MI after 48 hours of symptom onset * Pregnancy or lactating * Refuse to participate * No national health insurance (No French social security number)

Locations (1)

Institut Coeur-Poumon, CHU

Lille, France

RECRUITING

Outcomes

Primary Outcomes

MACE: Major adverse cardiovascular events

A composite of cardiovascular death, ischemic stroke, myocardial infarction, systemic embolism, acute limb ischemia, coronary revascularization, hospitalization for heart failure

Time frame: at 5 years

Secondary Outcomes

Cardiovascular death

Time frame: at 5 years

Myocardial infarction

Time frame: at 5 years

Ischemic stroke

Time frame: at 5 years

Systemic embolism

Time frame: at 5 years

Acute limb ischemia

Time frame: at 5 years

Coronary revascularization

Time frame: at 5 years

Hospitalization for heart failure

Time frame: at 5 years

All-cause death

Time frame: at 5 years

Bleeding as assessed by Bleeding Academic Research Consortium (BARC)

Time frame: at 5 years

Bleeding as assessed by GUSTO Bleeding Criteria

Global Utilization Of Streptokinase And Tpa For Occluded Arteries (GUSTO) definition for bleeding range to 1. Severe or Life-threatening/ 2. Moderate/ 3. Mild

Time frame: at 5 years

Bleeding as assessed by Thrombolysis in Myocardial Infarction (TIMI) criteria

Time frame: at 5 years

Bleeding as assessed by ISTH definitions

Time frame: at 5 years

Central Contacts

Gilles Lemesle, MD

CONTACT

03 20 44 45 61 gilles.lemesle@chru-lille.fr

Data from ClinicalTrials.gov

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