A Study Investigating the Safety and Tolerability of an Immune Treatment in Cancer Patients With Lesions to the Skin

Inclusion Criteria: 1. Age \> 18 years old 2. Must have measurable or evaluable metastatic disease (at least more than 1 lesion) as evidenced by physical exam or imaging 3. Must have an identifiable metastatic lesion of the skin, subcutaneous tissue, or lymph node amenable to intratumoral injection. This includes all solid tumors as well as metastatic melanoma and/or melanoma with in-transit metastases. 4. ECOG performance status \< 1 5. Histologically confirmed diagnosis of refractory or relapsed metastatic disease 6. Required values for screening laboratory tests: * Absolute neutrophil count (ANC) \> 1000/mm3 independent of growth factor support * Platelets \> 75,000/mm3 * Hemoglobin \> 8 g/dl * Creatinine clearance \> 40 ml/min for the dose-escalation phase, \>25 ml/min in dose expansion phase (if safety data from dose escalation indicate this is possible) * AST/ALT \< 3 x ULN * Bilirubin \< 1.5 x ULN (except for participants with Gilbert's Syndrome or of non-hepatic origin) 7. Patients must have refractory or relapsed disease and have must have exhausted all standard-of-care therapy for their disease 8. Must be at least 4 weeks since treatment with checkpoint inhibitors or other antibody-based therapy or investigational agents 9. Must be at least 2 weeks since chemotherapy, targeted small molecule therapy, cytokine therapy, or radiation therapy, and be recovered from any clinically significant toxicity experienced during treatment. 10. If sexually active male or female, and participating in sexual activity that could lead to pregnancy, agrees to use two effective methods of contraception (i.e. condom with spermicide, diaphragm with spermicide, hormone-eluting IUD, hormone-based contraceptive with condom). For females, these restrictions apply for 1 month after the last dose of study drug. For males, these restrictions apply for 3 months after the last dose of study drug. Men must agree not to donate sperm during and after the study. Female study participants of reproductive potential are defined as pre-menopausal women who have not had a sterilization procedure (e.g. hysterectomy, bilateral oophorectomy, tubal ligation or salpingectomy). Women are considered menopausal if they have not had a menses for at least 12 months and have a FSH of greater than 40 IU/L or if FSH testing is not available, they have had amenorrhea for 24 consecutive months. 11. Women of childbearing potential must have a negative (beta-human chorionic gonadotropin \[b-hCG\] pregnancy test at screening, as well as a negative pregnancy test prior to each treatment 12. Life expectancy greater than 16 weeks (should be evaluated by a prognostic score, e.g., Royal Marsden score). 13. Able to comply with the treatment schedule as determined by the participant and the LIP Exclusion Criteria: 1. Concurrent anticancer therapy including investigational agents. This includes topical therapeutic agents. 2. History of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced pneumonitis, organizing pneumonia (i.e. bronchiolitis obliterans, cryptogenic organizing pneumonia), risk of pulmonary toxicity, or evidence of active pneumonitis on screening chest CT scan. 3. History of radiation pneumonitis in the radiation field (fibrosis) is permitted 4. Patients with active hepatitis B (defined as having a positive hepatitis B surface antigen (HBsAg) test at screening. 5. Patients with past/resolved hepatitis B virus (HBV) infection (defined as having a negative HBsAg and a positive antibody to hepatitis B core antigen antibody test) are eligible only if polymerase chain reaction is negative for HBV RNA. HBV DNA must be obtained in these patients prior to Cycle 1, Day 1. 6. History of stroke or intracranial hemorrhage within 6 months prior to enrollment. 7. Has spinal cord compression not definitively treated with surgery and/or radiation or previously diagnosed and treated spinal cord compression without evidence that disease has been clinically stable for \> 2 weeks prior to screening. 8. Vaccinated with live, attenuated viral vaccines within 4 weeks of enrollment. 9. Known history of human immunodeficiency virus (HIV) or any uncontrolled active systemic infection. 10. Major surgery or a wound that has not fully healed within 4 weeks of enrollment. 11. Treatment with an immunosuppressive regimen of corticosteroids or other immunosuppressive medication (e.g., methotrexate, rapamycin) within 30 days of study treatment. Note: patients with adrenal insufficiency may take up to 5 mg of prednisone or equivalent daily. Topical and inhaled corticosteroids in standard doses are allowed. 12. Severe infections within 4 weeks prior to Cycle 1, Day 1, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia. 13. Signs and symptoms of infection within 2 weeks prior to Cycle 1, Day 1. 14. Any investigational therapy within 28 days prior to initiation of study treatment. This includes topical or injected agents. 15. Significant cardiovascular disease (i.e., NYHA class 3 congestive heart failure; myocardial infarction within the past 6 months; unstable angina; coronary angioplasty within the past 6 months; uncontrolled atrial or ventricular cardiac arrhythmias. 16. Autoimmune disease including systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, Sjogren's syndrome, autoimmune thrombocytopenia, history of uveitis or other autoimmune disease if clinically significant. 17. Patients with clinically active brain metastases are excluded. Patients with stable brain metastasis (with or without intervention) are eligible. Patients with previously irradiated lesions are eligible provided patient is \>4 weeks beyond completion of cranial irradiation and \>3 weeks of corticosteroid therapy. 18. Known history of leptomenigeal disease, patients with metastases to the brain stem, midbrain, pons, or medulla, and patients with metastases with 10 mm of the optic apparatus (optic nerve and chiasm) will be excluded from the study. 19. Requires anticoagulation with warfarin or equivalent vitamin K antagonists. 20. Has had a pulmonary embolism or any other thromboembolic event within 6 months prior to study entry. 21. Prior toxicities from previous cancer therapy, including checkpoint inhibition, that have not regressed to Grade \< 1 severity (NCI CTCAE v4.03, or later versions) within 28 days before Cycle 1, Day 1, with the exception of alopecia. 22. Active hepatitis C are excluded. Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA. 23. Any surgical procedure within less than 14 days of the first receipt of study drug. Major surgical procedure within 28 days prior to Cycle 1, Day 1 or anticipation of the need for a major surgical procedure during the study other than for diagnosis. 24. Pregnant or breast feeding 25. Active infection or with a fever \>38.5o C within 3 days prior to the first scheduled treatment. 26. Any medical history, including laboratory results, deemed by the investigator to be likely to interfere with their participation in the study, or to interfere with the interpretation of the results, or any social condition that, in the opinion of the Investigator, might pose additional risk to the participant or confound the results of the study.