Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea

St. Anne's University Hospital Brno, Czech Republic87 enrolled

Overview

Comparison of the prevalence of obstructive sleep apnea (OSA), measured by polysomnography in normal weight patients with central obesity by body mass index (BMI) and waist hip ratio (WHR), with normal weight patients without central obesity by BMI and WHR. Evaluation of arterial stiffness and vascular age in normal weight patients with central obesity and in normal weight patients without central obesity. Determination of the exercise response characteristics in OSA patients.

Body composition (the distribution of adipose tissue) appears to be a risk factor for the prevalence of obstructive form of sleep apnea. The investigators expect a higher prevalence of this serious sleep pathology in normal weight patients with central obesity than in normal weight patient without central obesity. In normal weight patients with central obesity also endothelial dysfunctions, abnormal exercise response to dynamic load and abnormal circadian patterns of blood pressure and heart rate can be expected. There are theoretical assumptions for this hypothesis but relevant studies on sufficiently large samples of patients have not been done. The investigators will also compare the lipid profile in normal weight patients with central obesity with those of normal weight patients without central obesity.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sleep Disorder Body Fat Distribution

Interventions

Overnight polysomnographyDEVICE

Overnight polysomnography will be performed in a sleep laboratory (EEG, EOG, EMG, ECG, respiratory movements of the chest and abdomen, oro-nasal airflow, and O2 saturation will be examined

Eligibility

Sex: ALLMin age: 25 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria central obesity group: * BMI 18.5 - 24.9 kg/m2 for both men and women * WHR more than 0.9 for men and 0.85 for women * no history of myocardial infarction, stroke, atrial fibrillation, previous diagnosis of OSA or its treatment. Inclusion Criteria without central obesity group: * BMI 18.5 - 24.9 kg/m2 for men and women * WHR selected from the lowest tertile of WHR distribution for both men and women Exclusion Criteria: * acute infection * known diagnosis of chronic renal or cardiac failure * taking drugs that affect sleep (stimulants, hypnotics, antidepressants, antipsychotics, anxiolytics, antihistamines, corticosteroids, theophylline, anti-parkinsonic drugs, anticonvulsants, morphine-type analgetics)

Locations (1)

St. Anne's University Hospital

Brno, Czechia

Outcomes

Primary Outcomes

Apnea hypopnea index

Apnea hypopnea index will be measured in both groups

Time frame: Through study completion, an average of 1 year

Secondary Outcomes

Cardio Ankle Vascular Index (CAVI)

Noninvasive arterial stiffness and vascular age index CAVI will be measured in both groups

Time frame: Through study completion, an average of 1 year

Response on ergo-spirometry test

Cardiopulmonary exercise test parameters (oxygen consumption at peak exercise (ml/kg/min) and VE/VCO2 slope) will be measured in both groups.

Time frame: Through study completion, an average of 1 year

Ambulatory 24-hour blood pressure measurement (ABPM)

Ambulatory 24-hour blood pressure measurement (ABPM) will be analyzed conventionally and chronobiologically in both broups

Time frame: Through study completion, an average of 1 year

Data from ClinicalTrials.gov

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