This study evaluates the effect of zinc over the duration, severity and relapse of acute diarrheic disease, in children between 6 and 59 months of age. One study group will receive a tablet that contains 20 mg of zinc, and the other study group will receive a tablet,that does not contain zinc, it is a tablet that investigators will use as control.
In Mexico acute diarrheal diseases mortality in children continues to be a public health issue, being between the main causes of morbidity and mortality, with an important load for the health systems. Consequently, there exists a necessity for the implementation of alternate strategies for this condition, nutrition being one of the pillars to strengthen. Zinc administration during the diarrhea episode is a simple intervention for clinical picture reduction and relapse. The recommendation of including zinc in the treatment of ADD is not part of the Mexican normativity. The evaluation of the efficacy of zinc administration in Mexican children is insufficient and a program or national strategy for zinc treatment does not exist. The objective of this study is evaluates the efficacy of oral zinc sulfate administration, during the diarrhea clinic picture in children of Mexico City.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
529
zinc 20mg tablets
Sugar pill manufactured to mimic zinc 20mg tablet
Hospital Pediatrico de Coyoacan
Mexico City, Mexico
Instituto Nacional de Pediatria
Mexico City, Mexico
Hospital Pediatrico La Villa
Mexico City, Mexico
Hospital Pediatrico de Iztapalapa
Mexico City, Mexico
Diarrhea duration
Number of hours from the inclusion of the patient until the end of the diarrhea. The end of diarrhea was defined as the last diarrhea evacuation followed by a 48 hr period without diarrhea
Time frame: 10 days
Stool frequency
Number of stools during during the acute diarrheic disease
Time frame: 10 days
diarrheic disease recurrence
Number of acute diarrheal episode, after the first episode
Time frame: 3 and 6 months
zinc serum concentration
Difference of zinc serum concentration after the oral treatment for 10 days with 20 mg of zinc, and its correlation with the duration of diarrhea , the number of total stools and relapse rates
Time frame: 3, 9, 20, 31, 61, 91 and 121 days
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Hospital Pediátrico de Tacubaya
Mexico City, Mexico
Centro de Salud Cultura Maya
Mexico City, Mexico
Centro de Salud San Andres Totoltepec
Mexico City, Mexico
Centro de Salud Topilejo
Mexico City, Mexico
Hospital Materno Infantil de Xochimilco
Mexico City, Mexico