Autonomic Nervous System and Sickle Cell Disease

Assistance Publique - Hôpitaux de Paris90 enrolled

Overview

Sickle cell disease (SCD) children and adults with asthma have an increased rate of vaso-occlusive crisis, acute chest syndrome episodes, and premature mortality when compared to those without asthma. We hypothesised that either asthma diagnosis and/or bronchodilator treatment may aggravate SCD via their modulating effect on autonomic nervous system.

Heart rate variability during pulmonary function tests (spirometry, static volumes, DLCO/DLNO, exhaled NO at multiple flow rates) including salbutamol administration will be evaluated in patients with SCD (n=60) receiving asthma treatment or not, as compared to asthmatic children without SCD (n=30) matched for ethnicity

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Rate Variability (ANS Function)

Eligibility

Sex: ALLMin age: 6 YearsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age from 8 to 16 years (≥ 8 years and \< 16 years) (spirometry and DLCO study feasible) * Sub-Saharan African or Caribbean ethnic origin. * child with sickle cell disease referred for monitoring of respiratory function in the framework of its sickle cell disease and whether or not it presents a possible disease asthmatic (asthma treatment prescribed in the past year) * or asthmatic child (typical functional signs + history of exacerbation severe hospitalized or reversible obstructive pulmonary disorder) not sickle cell * addressed for respiratory function monitoring Exclusion Criteria: * Refusal to participate (lack of consent) * Sickle cell child of North African origin

Locations (1)

Robert Debre Hospital

Paris, France

Outcomes

Primary Outcomes

To assess the effect of salbutamol administration on ANS in these SCD children (with and without asthma) and in control asthmatics (without SCD)

heart rate variability after salbutamol administration

Time frame: cross-sectional, one hour

Secondary Outcomes

To assess ANS functions in patients with SCD receiving asthma treatment or not, as compared to asthmatic children without SCD matched for ethnicity

baseline heart rate variability

Time frame: cross-sectional, one hour

Data from ClinicalTrials.gov

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