The overall aim of the present research program is to determine how a healthy whole-diet approach impacts on cardiometabolic health in adults. With its interdisciplinary approach, the study depicts mechanisms behind disease progression and the impact of healthy dietary patterns on changes in markers of low-grade systemic inflammation together with the exploration of knowledge and attitudes about healthy diets. The study has a preventive character as it targets older adults (65+) without manifest disease.
This two arm randomized-controlled study includes the following groups: Controls and Healthy Diet group. The study will particularly address the following aspects: * determine food literacy, perceived attitudes and barriers for the adoption of new dietary habits incorporating increased fruit and vegetable intake in adults. * explore the effects of a randomized controlled intervention promoting healthy dietary patterns (increased intakes of fruit and vegetable, whole-grain, nuts and low fat dairy products and replacing saturated with unsaturated fats and decreased red meat and salt consumption) for a period of 4 months on components of the metabolic syndrome, a large panel of pro- and anti-inflammatory biomarkers and metabolomic profile in adults. * assess the long-term adherence to healthy dietary patterns in adults. * provide support for behavioural change and evaluate participants' perception of this support.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
80
Receive counseling to meet guidelines for healthy dietary patterns
Örebro University
Örebro, Sweden
Change in blood glucose
Blood glucose (mmol/L) assessed using chemistry kits from Ortho-Clinical Diagnostics on a Vitros-5.1 analyzer platform (Clinical Diagnostics, Raritan, NJ, United States)
Time frame: Before and after 16 weeks
Change in plasma triglycerides
Plasma triglycerides (mmol/L) : assessed using chemistry kits from Ortho-Clinical Diagnostics on a Vitros-5.1 analyzer platform (Clinical Diagnostics, Raritan, NJ, United States)
Time frame: Before and after 16 weeks
Change in high-density lipoprotein cholesterol
high-density lipoprotein cholesterol (mmol/L) : assessed using chemistry kits from Ortho-Clinical Diagnostics on a Vitros-5.1 analyzer platform (Clinical Diagnostics, Raritan, NJ, United States)
Time frame: Before and after 16 weeks
Change in waist circumference
waist circumference (cm) assessed by a steel tape
Time frame: Before and after 16 weeks
Change in diastolic and systolic blood pressure (mmHg)
diastolic and systolic blood pressure (mmHg) assessed using a manual sphygmomanometer
Time frame: Before and after 16 weeks
Change in intake of fruit and vegetable
\- Fruit and vegetable intake assessed on a 7 scale-item where the lowest value of 1, indicates an intake less than 1 per month, and 7 an intake of at least 5 servings /day.
Time frame: Before and after 16 weeks
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