Pupillometer as a Pain Index During General Anesthesia

Seoul National University Hospital35 enrolled

Overview

This study evaluates the validity of pupil diameter as an indicator of pain during surgery under general anesthesia.

Pupil diameter is known to be strongly correlated with sympathetic tone. During surgery under general anesthesia, there is no standardized means of pain assessment. As pain activates sympathetic nervous system, we hypothesized that pupil diameter can be a marker for pain during surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anesthesia, General Pupil Pain

Interventions

Pupil sizeDEVICE

Measures the diameter of pupil before and after painful stimuli

Eligibility

Sex: ALLMin age: 3 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children undergoing surgery under general anesthesia with total time of less than two hours Exclusion Criteria: * Children whose parent or legal guardian declined to enroll * Any use of opioids during surgery * History of hypersensitivity to any anesthetic agents * Any medication that can affect sympathetic nervous activity * Presence of underlying ophthalmologic disease

Locations (1)

SNUH

Seoul, Jongno Gu, South Korea

Outcomes

Primary Outcomes

Pupil diameter

Pupil diameter before and after painful stimuli (skin incision, train-of-four stimulation)

Time frame: From start of anesthesia to end of anesthesia

Secondary Outcomes

Bispectral index

Bispectral index before and after painful stimuli (skin incision, train-of-four stimulation)

Time frame: From start of anesthesia to end of anesthesia

Pleth variability index

Pleth variability index before and after painful stimuli (skin incision, train-of-four stimulation)

Time frame: From start of anesthesia to end of anesthesia

Data from ClinicalTrials.gov

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