Cordyceps cicadae mycelia was tested for amelioration of dry eye symptoms through dietary supplementation. Its efficacy in relief of human dry eye status was assessed by randomized, double-blinded tests, including multiple assessments. The results were compared between the placebo group and the experimental group.
Former animal studies had shown that Cordyceps cicadae mycelia can effectively ameliorate UVB-induced dry eye symptoms. This study further investigated its efficacy in human dry eye status by randomized, double-blinded tests, including dry eye questionnaires, blood tests, salivary tests, tear volume test, intra-ocular pressure assessments, ocular surface photography, corneal fluorescein stain, tear film breakup time test, fundus photography, and cornea impression cytology. All tests were performed again after 3 months of dietary supplement of either samples or placebo. A total of 97 participants completed the trial. The data were analyzed by paired-t test and compared between the placebo and the experimental groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
97
Cordyceps Cicadae Mycelia supplement for 3 months
Placebo was given to participants.
tear film breakup time
Tear film breakup time was used for tear quality assessments.
Time frame: day 1 to day 90.
Cornea surface scores based on Efron grading system
Cornea surface scores based on Efron grading system was used for assessment of cornea surface damages.
Time frame: day 1 to day 90.
Intra-ocular pressure
Intra-ocular pressure was taken to assess eye pressure.
Time frame: day 1 to day 90.
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