PTNS on Urinary and Global Quality of Life in MS Patients

University of Michigan23 enrolled

Overview

This is a single-centered, prospective, longitudinal, observational cohort study of patients with MS who suffer from lower urinary tract symptoms (LUTS) and are refractory to two prior treatment modalities who have elected to pursue PTNS therapy for LUTS.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple Sclerosis Lower Urinary Tract Symptoms Neurogenic Bladder Overactive Bladder Urinary Incontinence Urinary Urge Incontinence

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Multiple Sclerosis * Lower urinary tract symptoms (urinary frequency, urgency and/or incontinence) * Failed prior first and second line therapy (behavioral and pharmacotherapy) * Electing for Posterior Tibial Nerve Stimulation therapy for urinary symptoms * Patients performing Intermittent Catheterization are Eligible Exclusion Criteria: * Indwelling catheters (urethral or suprapubic) * Currently pregnant or planning pregnancy * Unable to attend weekly office visits for PTNS * Urodynamic findings of bladder outlet obstruction History of: bladder reconstruction (augmentation cystoplasty, catheterizable channel) cystectomy bladder stones pacemaker or defibrillator malignancy of bladder sacral neuromodulation intravesical injection of onabotulinum toxin within 9 months

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Urinary Frequency and/or Urinary Incontinence Episodes on 3 day voiding diary

Change from baseline in the median number of urinary frequency and/or urinary incontinence episodes on a 3 day voiding diary at 3, 12, and 24 months

Time frame: up to 24 months.

Data from ClinicalTrials.gov

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