Effect of Epinephrine on Post-polypectomy Pain

Indiana University22 enrolled

Overview

Epinephrine is widely used in endoscopic mucosal resection of large polyps to prevent post-polypectomy bleeding. No previous studies looked at increase in immediate post-polypectomy pain with the use of epinephrine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Colonic Polyp

Interventions

EpinephrineDRUG

Epinephrine in the submucosal injection fluid

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria 1. Patients aged 18 years and over 2. Patients scheduled for treatment of large (≥ 20 mm) colorectal polyps 3. Able to sign informed consent Exclusion Criteria 1. Patients previously enrolled in the study 2. Pedunculated polyps 3. Polyps not amenable to endoscopic resection 4. Patients allergic or sensitive to epinephrine 5. Patients with coronary artery disease who have had a myocardial infarction in the past year, or had coronary stenting in the past year, or had angina in the past year. 6. Patients electing anesthesia other than monitored anesthesia care with propofol (MAC) for colonoscopy

Locations (1)

Indiana University Hospital

Indianapolis, Indiana, United States

Outcomes

Primary Outcomes

Immediate Post-polypectomy Pain

Pain related by the participant on a 0-100 visual analog scale; patients will be asked to mark their pain level on a straight vertical line 100 mm long and this point will be measured with a ruler for pain score. Possible values are zero- indicating no pain at all to 100-indicating worst imaginable pain

Time frame: 30 minutes after the procedure

Immediate Post Polypectomy Pain (1hour)

Time frame: 1 hour after procedure

Secondary Outcomes

en Bloc Resection

Number of polyps removed en bloc (in 1 piece) vs number of polyps removed piecemeal (in more than 1 piece)

Time frame: During the colonoscopy procedure, an average of 47.3 minutes

Sydney Resection Quotient

size of the polyp in mm divided by the number of pieces the polyps is removed in

Time frame: During the colonoscopy procedure, an average of 47.3 minutes

Quality of the Mound

Endoscopist impression of lift provided by the submucosal injection: excellent/adequate or insufficient. Excellent is the best rating and insufficient is the worst rating on this scale.

Time frame: During the colonoscopy procedure, an average of 47.3 minutes

Frequency of Immediate Bleeding

Number of polyps with intraprocedural bleeding during removal

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.