A Study to Determine the Drug Level Profile of Different formulations of BMS-986165 Tablets
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
33
Participants will receive BMS- 986165 -01 in prototype formulation
Participants will receive BMS-986165 in tablet form.
Participants will receive a previously dosed BMS-985165-01 Prototype Tablet at the same dose level following administration of famotidine
Quotient Sciences
Nottingham, United Kingdom
Maximum observed plasma concentration (Cmax) for BMS-986165
Time frame: Day 1 of treatment
Area under the serum concentration-time curve from time zero to time of last quantifiable concentration- AUC(0-T) for BMS- 986165
Time frame: Day 1 of treatment
Area under the plasma concentration-time curve from time zero extrapolated to infinite time- AUC(INF) for BMS-986165
Time frame: Day 1 of treatment
Time to maximum observed plasma concentration-(Tmax) for BMS -986165
Time frame: Day 1 of treatment
Apparent plasma elimination half-life- (T-HALF) for BMS-986165
Time frame: Day 1 of treatment
Area under the concentration-time curve from time zero to 24 hours post- (AUC 0-24) for BMS-986165
Time frame: Day 1 of treatment
Apparent clearance -(CL/F) for BMS-986165
Time frame: Day 1 of treatment
Concentration observed at 24 hours-(C24) for BMS-986165
Time frame: Day 1 of treatment
Concentration observed at 12 hours-(C12) for BMS-986165
Time frame: Day 1 of treatment
Incidence of non-serious adverse events(AE's) leading to discontinuation of study therapy.
Time frame: Approximately 16 weeks
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Incidence of serious adverse events (SAE) leading to discontinuation of study therapy.
Time frame: Approximately 16 weeks.
Incidence of adverse events (AEs) leading to discontinuation of study therapy.
Time frame: Approximately 16 weeks.