Vitamin D in Systemic Sclerosis Patients With Periodontitis

University of Messina168 enrolled

Overview

Vitamin D has been considered to possess anti-inflammatory and antimicrobial activity which may be a link for the known interaction of Systemic Sclerosis (SSc) and coronary heart disease (CHD). This study investigated the association between serum vitamin D levels and SSc and periodontitis in patients with SSc, CP and with CHD. Furthermore, the objective was to determine if periodontitis and CHD had an impact on serum vitamin D levels.

Using a cross-sectional design, a total of 42 patients with SSc, 43 patients with CHD, 41 patients with both SSc and CP, and 42 healthy patients were enrolled in the present study.

Study Type

OBSERVATIONAL

Enrollment

168

Conditions

Vitamin D Deficiency

Interventions

ObservationOTHER

Evaluation of Vitamin D levels and correlation of Vitamin D levels level with periodontal and cardiovascular disease

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of at least twenty teeth * CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm; * Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs * Presence of ≥40% sites with bleeding on probing (BOP) Exclusion Criteria: * Intake of contraceptives * Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study * Status of pregnancy or lactation * Previous history of excessive drinking * Allergy to local anaesthetic * Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Locations (1)

University of Messina

Messina, Italy

Outcomes

Primary Outcomes

Vitamin D levels

Evaluation of serum Vitamin D levels

Time frame: 1 year

Data from ClinicalTrials.gov

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