Nab-paclitaxel Based Regimens VS Paclitaxel Based Regimens in Neoadjuvant Treatment for TNBC

Inclusion Criteria: * Female, aged ≥ 18 yrs and ≤70 yrs； * Histological confirmation of Unilateral primary invasive breast cancer, cT2-4NanyM0, planning to receive neoadjuvant chemotherapy； * The expression of ER\<10%，PR \<10% and Her-2 negative by immunohistochemical, if HER2 expression ++, further FISH test confirmed no amplification of Her-2 gene； * ECOG performance status 0-1； * LVEF≥55%； * Bone marrow function: neutrophils ≥ 1.5×109/L, platelets ≥ 100×109/L, hemoglobin ≥ 90 g/L； * Liver and renal function：Serum creatinine ≤ 1.5x ULN；Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5x ULN；Total bilirubin ≤ 1.5x ULN or when patients with Gilbert's syndrome ≤ 2.5x ULN； * The patient has good compliance with the planned treatment, understands the research process of the study and signs a written informed consent form. Exclusion Criteria: * Cytotoxic chemotherapy, endocrine therapy or radiation therapy for any reason； * New York Heart Association (NYHA) score identifies patients with heart disease above grade II (including grade II)； * Patients with severe systemic infections or other serious illnesses； * Patients known to be allergic or intolerant to chemotherapeutic drugs or their excipients； * Combined with other malignant tumors or had malignant tumors other than breast cancer in the past 5 years, except for cervical carcinoma in situ and non-melanoma skin cancer that have been fully treated； * Women of childbearing age who are pregnant or lactating and who refuse to take appropriate contraceptive measures during the trial； * Participated in other experimental studies within 30 days before the first dose of study drug administration * Researchers judged patients who were unsuitable for this study.