Gas Exchange and CT Effects of PEEP in ARDS

Policlinico Hospital13 enrolled

Overview

The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results

In ARDS patients on mechanical ventilation, we will compare model-based estimation of gas exchange parameters (shunt, ventilation/perfusion mismatch) with CT-based estimation of effects of low and high PEEP

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

ARDS

Interventions

ALPEDIAGNOSTIC_TEST

Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O Measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- ARDS patients requiring mechanical ventilation Exclusion Criteria: * \<18 years old * Requirement of extracorporal life support * Hemodynamic instability * Barotrauma

Locations (1)

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, MI, Italy

Outcomes

Primary Outcomes

Gas Exchange and lung recruitability at diferent PEEP levels

Gas exchange (At PEEP 5 and 20 cm H2O), CT scan (At PEEP 5, 20 and 45 cm H2O)

Time frame: Approximately two hours

Secondary Outcomes

Physiologic Parameter 1

Hemodynamic assessment at different PEEP levels

Time frame: Approximately two hours

Physiologic Parameter 2

Respiratory mechanics at different PEEP levels

Time frame: Approximately two hours

Data from ClinicalTrials.gov

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