Exploratory Study of CD19-targeted Chimeric Antigen Receptor T Cells(BZ019) for Relapsed and Refractory B-cell Lymphoma

Inclusion Criteria: 1. Written informed consent must be obtained prior to any screening procedures 2. Age ≥ 18 years subjects with Relapsed or refractory large B-cell lymphoma, including: DLBCL,NOS, high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, transformed B-cell lymphoma, primary mediastinal B-cell lymphoma (PMBCL). * No response for the last chemotherapy: * Progressive disease after the last chemotherapy or * Stable disease after the last chemotherapy, and the maintenance time for stable disease was no longer than 6 month after last dose. * Either having failed autologous Hematopoietic stem cell transplantation (ASCT), or being ineligible for or not consenting to ASCT * Refractory disease after ASCT or relapsed disease within 12 months after last ASCT (histologically confirmed) or * No response or relapsed disease for the last therapy after ASCT. 3. Subjects must be accepted adequate treatment, including at least: * Treated by CD20 monoclonal antibody (Rituximab) except for CD20 negative. * Chemotherapy including anthracycline 4. Measurable disease at time of enrollment according to the revised international working group response criteria for malignant lymphoma. 5. Life expectancy ≥12 weeks 6. Eastern Cooperative Oncology Group (ECOG) performance status that is either 0 or 1 at screening. 7. Adequate organ function: * Renal function defined as: * A serum creatinine of ≤1.5 x Upper Limit of Normal(ULN) or * Estimated Glomerular Filtration Rate (eGFR) ≥ 60 mL/min/1.73 m2 * Liver function defined as: * Alanine Aminotransferase (ALT) ≤ 5 times the ULN for age * Bilirubin ≤ 2.0 mg/dl with the exception of patients with Gilbert-Meulengracht syndrome; patients with Gilbert-Meulengracht syndrome may be included if their total bilirubin is ≤ 3.0 x ULN and direct bilirubin ≤ 1.5 x ULN * Must have a minimum level of pulmonary reserve defined as ≤ Grade 1 dyspnea and pulse oxygenation \> 91% on room air 8. Hemodynamically stable and Left Ventricle Ejection Fraction (LVEF) ≥ 45% confirmed by echocardiogram or Multigated Radionuclide Angiography (MUGA) 9. Adequate bone marrow reserve without transfusions defined as: * Absolute neutrophil count (ANC) \> 1000/μL * Absolute lymphocyte count (ALC) ≥ 300/μL * Platelets ≥ 50000/μL * Hemoglobin \> 8.0 g/dl 10. Must have an apheresis product of non-mobilized cells accepted for manufacturing. 11. The following medications are excluded: * Steroids: Therapeutic doses of steroids must be stopped \> 72 hours prior to BZ019 infusion. However, the following physiological replacement doses of steroids are allowed: \< 6 - 12 mg/m2/day hydrocortisone or equivalent * Immunosuppression: Any immunosuppressive medication must be stopped ≥ 4 weeks prior to enrollment * Antiproliferative therapies other than lymphodepleting chemotherapy within two weeks of infusion * Antibody use including anti-CD20 therapy within 4 weeks prior to infusion or 5 half-lives of the respected antibody, whichever is longer * CNS disease prophylaxis must be stopped \> 1 week prior to BZ019 infusion (e.g. intrathecal methotrexate) 12. Women of child-bearing potential (defined as all women physiologically capable of becoming pregnant) and all male participants must agree to use highly effective methods of contraception for at least 12 months following BZ019 infusion and until CAR T cells are no longer present by PCR on two consecutive tests Exclusion Criteria: 1. Prior treatment with any prior anti-CD19/anti-CD3 therapy, or any other anti-CD19 therapy 2. Treatment with any prior gene therapy product, include CAR-T cell therapy. 3. Active Central Nervous System (CNS) involvement by malignancy or secondary CNS involvement 4. History or presence of clinically relevant CNS pathology such as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, or self-immune disease with CNS involvement. 5. Prior allogeneic HSCT 6. Eligible for and consenting to ASCT 7. Chemotherapy other than lymphodepleting chemotherapy within 2 weeks of infusion 8. Investigational medicinal product within the last 30 days prior to screening 9. Prior radiation therapy within 2 weeks of infusion 10. Active replication of or prior infection with hepatitis B or active hepatitis C( HCV RNA positive ) 11. HIV positive patients 12. Uncontrolled acute life threatening bacterial, viral or fungal infection (e.g. blood culture positive ≤ 72 hours prior to infusion) 13. Unstable angina and/or myocardial infarction within 6 months prior to screening 14. Previous or concurrent malignancy with the following exceptions: * Adequately treated basal cell or squamous cell carcinoma (adequate wound healing is required prior to study entry) * In situ carcinoma of the cervix or breast, treated curatively and without evidence of recurrence for at least 3 years prior to the study * A primary malignancy which has been completely resected and in complete remission for ≥ 5 years 15. Pregnant or nursing (lactating) women 16. Cardiac arrhythmia not controlled with medical management 17. Patients on oral anticoagulation therapy within 1 week prior to BZ019 infusion. 18. Prior treatment with any adoptive T cell therapy 19. Patients with active neurological auto immune or inflammatory disorders(e.g. Guillain Barre Syndrome, Amyotrophic Lateral Sclerosis) 20. Other protocol-related inclusion/exclusion may apply.