Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool

Universität des Saarlandes30 enrolled

Overview

Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.

Subjects to undergo surgery with opening of the jejunum will be sampled with sterile swabs from peritoneum and the inside of the jejunum. A swab will also be taken from the rectum. The peritoneum is regarded as a sterile place until today. We try to either verify this, we also could find a scientific base for theories like leaky gut or other forms of bacterial migration through the intestinal wall. Many of these patients undergo bariatric surgery. Many of them do have a dramatic change in glucose metabolism immediate after surgery. Therefore stool swabs will be taken before and 5 days after surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity Diabetes Mellitus Fatty Liver, Nonalcoholic Leaky Gut Syndrome Chronic Pancreatitis

Interventions

Microbial SwabDIAGNOSTIC_TEST

Swabs will be taken from peritoneum and jejunum (intraoperatively), rectum, and stool

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * abdominal surgery containing opening of jejunum * singing of consent Exclusion Criteria: * inflammative condition (appendicitis, pancreatitis, Crohn, Colitis ulcerous, cholecystitis and similar)

Locations (1)

Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland,

Homburg/Saar, Germany

Outcomes

Primary Outcomes

Characterization of microbiome

Previously uncharacterized sites: jejunum, peritoneum

Time frame: intra-operative

Data from ClinicalTrials.gov

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