Norepinephrine and Phenylephrine, Which Better for Elderly?

The Second Affiliated Hospital of Dalian Medical University100 enrolled

Overview

this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative hypotension, and to find the safest and most effective vasopressor for elderly.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

Hypotension

Interventions

norepinephrineDRUG

patient who was received the treatment of norepinephrine

PhenylephrineDRUG

patient who was received the treatment of phenylephrine

Eligibility

Sex: ALLMin age: 60 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * radical resection of colorectal or gastric cancers, * age over 65 years old, * surgical time longer than 2hours, * the American Society of Anesthesiologists(ASA) classification of II or III Exclusion Criteria: * history of severe cardiovascular diseases, * history of severe liver and kidney diseases, * evidence of arrhythmia on EKG, * use of positive end-expiratory pressure (PEEP) during mechanical ventilation; * conditions with relative contraindication for arterial catheterization

Locations (1)

The Second Hospital of Dalian Medical University

Dalian, Liaoning, China

RECRUITING

Outcomes

Primary Outcomes

hemodynamics- (CO)cardiac output

(CO)cardiac output in Litres per minute. the indicator reflect the patients hemodynamic, which measured by the FloTrac/Vigileo 3.0

Time frame: change from patient enters the operating room to end of operation, assessed up to the whole operation

Tissue perfusion and oxygenation-(DO2) Oxygen delivery;

Blood samples from the radial artery and internal jugular vein were taken at the same time in three time points respectively to measure arterial and venous blood gas, and Measured tissue oxygenation according to Fick equation:DO2(ml/min/m2)=CaO2×10×CI, Arterial oxygen content (CaO2)=Arterial hemoglobin concentration(Hba)×1.36×arterial oxygen saturation(SaO2) + 0.0031×arterial oxygen pressure (PaO2) ;

Time frame: change from beginning of operation to end of operation, assessed up to the whole operation

Tissue perfusion and oxygenation-(VO2)Oxygen consumption;

Blood samples from the radial artery and internal jugular vein were taken at the same time in three time points respectively to measure arterial and venous blood gas, and Measured tissue oxygenation according to Fick equation:VO2(ml/min/m2)= (CaO2-CcvO2)×CI×10, Intravenous oxygen content (CcvO2)= Intravenous hemoglobin concentration (Hbv)×1.36×Venous oxygen saturation (ScvO2) + 0.0031×venous oxygen pressure (PcvO2);

Time frame: change from beginning of operation to end of operation, assessed up to the whole operation

Central Contacts

xiao z yang, MD,PHD

CONTACT

17709873399 xiaozhaoy2012@163.com

Data from ClinicalTrials.gov

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