Safety of Bosentan in Type II Diabetic Patients

Inclusion Criteria: * Signed informed consent; * Type II Diabetes Mellitus; * 18 or more years old Exclusion Criteria: * Pregnant or breastfeeding Women * Known allergy or intolerance to investigational product or any of its excipients * Severe corneal abnormalities * Any relevant ocular / ophthalmic pathology that may put study results at risk in the opinion of Principal Investigator * Any sign or symptom of Diabetes Retinopathy * Any ocular surgery in the 6 previous months to study inclusion * Uncontrolled diabetes in the previous 3 months to inclusion or HbA1c levels ≥ 9% at baseline. * Oxford Scale or OSDI scores compatible with study failure at inclusion visit. (Oxford ≥ 5 or OSTDI ≥ 13) * Previous hepatopathy history or signs of hepatopathy at baseline. * Contact lens use * Actual treatment with the commercially available presentation