Ultrafine Particles and Fetal Contamination

University Hospital, Bordeaux62 enrolled

Overview

The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.

Epidemiological studies have demonstrated the harmful effects of particulate air pollution on the progress of pregnancy and postnatal health. Experimental studies have suggested the transplacental passage of asbestos fibers, but despite the strong growth in the use and production of fine and ultrafine particles, no study has examined the permeability of the placenta to these compounds or the exposures fetuses that may result. The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lung; Premature Pollution; Exposure

Interventions

Pulmonary Tissue CollectionPROCEDURE

Pulmonary Tissue Collection

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: \- All women volunteers for whom a medical termination of pregnancy is proposed for a fetus older than 22 weeks (weight over 500g). Exclusion Criteria: * Refusal of participation of the patient. * Fetus with malformation syndrome affecting pulmonary perfusion.

Outcomes

Primary Outcomes

Presence of fine particles in fetal lung samples yes/no

Analysis in electron microscopy

Time frame: At the screening

Data from ClinicalTrials.gov

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