Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study

Inclusion Criteria: * Body mass index (BMI) : 18.0-30.0 kg/m2, inclusive, at screening * Weight : \>50 kg, at screening * Status : healthy subjects * Female subjects must be of non-childbearing potential (either surgically sterilized or physiologically incapable of becoming pregnant, or post-menopausal \[defined as spontaneous amenorrhoea for at least 1 year or spontaneous amenorrhoea for at least 6 months confirmed by a follicle stimulating hormone (FSH) result indicating a post-menopausal status\]) and have a negative pregnancy test at screening and at (each) admission to the clinical research center. As all female subjects must be of non-childbearing potential, they are not required to use any contraception during this study. * Male subjects must use adequate contraception and not donate sperm from (first) admission to the clinical research center until 90 days after the follow-up visit. Adequate contraception for the male subject (and his female partner) is defined as surgical sterilization (vasectomy), using hormonal contraceptives (implantable, patch, oral, injectable) or an intrauterine device or system combined with at least 1 of the following forms of contraception (barrier method): a diaphragm or cervical cap, or a condom. Also, total abstinence, in accordance with the lifestyle of the subject is acceptable. * Must have QTcF ≤450 ms and QTcB ≤450 ms (male subjects); QTcF ≤470 ms and QTcB ≤470 ms (female subjects), and PR-interval ≤200 ms for screening, and Day -1 and pre-dose ECG measurements of the (first) treatment period * Ability and willingness to abstain from alcohol and methylxanthine-containing beverages or food (coffee, tea, cola, chocolate, energy drinks) from 48 hours prior to (each) admission to the clinical research center * Willing and able to communicate and participate in the whole study * Willing and able to sign the ICF Exclusion Criteria: * A subject who meets any of the following exclusion criteria will not be eligible for inclusion in the study: * Male subjects who have currently pregnant partners or who have partners planning to be pregnant in the 90 days after discharge * Evidence or history of clinically significant oncological, pulmonary, chronic respiratory, hepatic, cardiovascular, hematological, metabolic, neurological, immunological, nephrological, endocrine or psychiatric disease, or current infection * Clinically relevant (as decided by the Principal Investigator \[PI\]) abnormalities in the 12-lead ECG, including asymptomatic bundle branch block * Family history of sudden death or of congenital prolongation of the QTc-interval or known congenital prolongation of the QTc-interval or any clinical condition known to prolong the QTc-interval * History of symptomatic cardiac arrhythmias or with clinically relevant bradycardia, heart rate ≤39 beats per minute (bpm) * Electrolyte disturbances, particularly hypokalemia, hypocalcemia or hypomagnesemia * Any condition that could possibly affect drug absorption, e.g. gastrectomy or diarrhea * History of post-antibiotic colitis * History of any drug or alcohol abuse in the past 2 years prior to screening * Subjects who regularly smoke more than 5 cigarettes a day * Receipt of an investigational drug or participation in another clinical research study within 90 days prior to the first dose of study drug * Subjects who are PRA employees, or immediate family members of PRA or Sponsor employees * Subjects who have previously been enrolled in this study * Use of moderate/strong inhibitors or inducers of CYP cytochromes or transporters within 30 days or 5 half-lives (whichever is longer) prior to the first dose of study drug * Consumption of grapefruit, grapefruit juice or grapefruit-related citrus fruits (e.g. Seville oranges, pomelos) within 14 days prior to the first dose of study drug * Use of prescription or non-prescription drugs and dietary supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study drug. With the exception of paracetamol (which may be used incidentally or for a short-term treatment at a maximum dose of 2 g per day) and hormone replacement therapy * Use of herbal supplements within 30 days prior to the first dose of study drug * Positive hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody or HIV-1 or HIV-2 antibody results * Clinically significant abnormal biochemistry, hematology or urinalysis as judged by the PI. In case of doubt the PI will discuss this with the medical monitor * Positive urine drug screen result at screening or admission to the clinical research center * Serious adverse reaction or serious hypersensitivity to any drug or the formulation excipients * Presence or history of allergy requiring treatment. Hayfever is allowed unless it is active * Donation or loss of \>100 mL of blood within 90 days prior to drug administration * Regular alcohol consumption in males \>21 units per week and females \>14 units per week (1 unit = 250 mL beer, 25 mL of 40% spirit or 125 mL of wine) * Subjects who do not have suitable veins for multiple venepunctures/cannulation as assessed by the PI or delegate at screening * Failure to satisfy the PI of fitness to participate for any other reason