Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria

Ain Shams University241 enrolled

Overview

The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.

Introduction: HEPATOCELLULAR CARCINOMA (HCC) is the second leading cause of cancer mortality worldwide. Living donor liver transplantation (LDLT) for HCC patients has emerged as a rewarding therapy for a cure and a successful alternative where a Deceased donor liver transplantation (DDLT) program is lacking. Therefore, trials for careful expansion to Milan criteria have been adopted. Aim of the study: To evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients

Study Type

OBSERVATIONAL

Enrollment

241

Conditions

Hcc

Interventions

living donor liver transplantationPROCEDURE

liver graft from a living donor

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patient transplanted for HCC eligible for transplant (no vascular invasion-no extra hepatic metastasis) * age\>18y Exclusion Criteria: * other etiology for liver transplant rather than HCC * patient not fit for surgery * age \>70y

Outcomes

Primary Outcomes

HCC recurrence

Recurrence of Hepatocellular carcinoma either intra-hepatic, extra-hepatic or both

Time frame: 3 years

Data from ClinicalTrials.gov

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