The investigators are conducting research to compare serum and urine titanium levels in children with early onset scoliosis who are being treated with certain types of metal spinal rods. These rods include traditional growing rods (TGR), magnetically-controlled growing rods (MCGR), and Vertical Expandable Prosthetic Titanium Rib (VEPTR). Children with metal rods may have elevated serum and urine titanium levels. These levels may remain elevated over time. The investigators will collect serum titanium levels from children with metal rods and children without metal rods to see if there are differences in their titanium levels. The investigators will then collect a second serum titanium level from children with metal rods at least 6 months later to see if the participants titanium levels remain elevated over time. The investigators will also collect urine titanium levels from children with metal rods to see if titanium is excreted in the urine.
Study Type
OBSERVATIONAL
Enrollment
38
Patients with growth-sparing instrumentation as treatment for early onset scoliosis, will have their titanium (serum and urine) levels tested, to evaluated if they have elevated titanium levels compared to a control group.
Michigan Medicine
Ann Arbor, Michigan, United States
Serum titanium levels between groups
Compare serum titanium levels in patients with EOS treated with titanium alloy TGR, MCGR, and VEPTR to age-matched controls.
Time frame: At enrollment
Serial serum titanium levels in scoliosis patients
Collect serial serum titanium levels in patients with EOS treated with TGR, MCGR, and VEPTR.
Time frame: Roughly 6 months apart
Urine titanium levels in scoliosis patients
Collect urine titanium levels in patients with EOS treated with TGR, MCGR, and VEPTR.
Time frame: At enrollment
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