Post-operative nausea and vomiting (PONV) in women undergoing subarachnoid anesthesia for Caesarean section is an important clinical problem. The aim of this study is to compare the effectiveness of oral carbohydrate loading to standard pre-operative fasting in patients undergoing elective cesarean section on the incidence and severity of PONV and biochemical parameters indicating ketosis.
Post-operative nausea and vomiting (PONV) in women undergoing subarachnoid anesthesia for Caesarean section is an important clinical problem. Known mechanisms underlying PONV are based on prolonged fasting, hypotension due to concomitant sympatholysis during anesthesia, bradycardia due to increased vagal tone, visceral stimulation during surgery and intrathecal administered opioids. However, the identification of patients exposed to this problem and appropriate perioperative preparation is of key importance. An analysis of risk factors for postoperative nausea and vomiting in patients undergoing elective cesarean section under spinal anesthesia is of major clinical importance. The aim of this study is a comparison of the effectiveness of oral carbohydrate loading strategy as compared with standard pre-operative fasting in patients undergoing elective cesarean section under spinal anesthesia on the incidence and severity of PONV and biochemical parameters indicating ketosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
140
Patients in the experimental arm will receive oral carbohydrate preparation at 2 hours prior to planned caesarian section.
Pomeranian Medical University
Szczecin, Poland
RECRUITINGPostoperative nausea and vomiting 6 hours after caesarian section.
The Postoperative Nausea and Vomiting (PONV) Intensity Scale 6 hours after caesarian section. Scale range: 0-50. The scale measures PONV intensity, where a score ≥50 defined clinically important PONV: PONV Intensity Scale=severity of nausea (1=mild, 2=moderate, 3=severe)×pattern of nausea (1=varying, 2=constant)×duration of nausea (in hours).
Time frame: 6 hours
Postoperative nausea and vomiting 24 hours after caesarian section.
The Postoperative Nausea and Vomiting (PONV) Intensity Scale 24 hours after caesarian section. Scale range: 0-50. The scale measures PONV intensity, where a score ≥50 defined clinically important PONV: PONV Intensity Scale=severity of nausea (1=mild, 2=moderate, 3=severe)×pattern of nausea (1=varying, 2=constant)×duration of nausea (in hours).
Time frame: 24 hours
Time to first peristalsis.
Moment of first peristalsis after operation (in hours).
Time frame: 24 hours
Time to first bowel movement.
Moment of first bowel movement after operation (in hours).
Time frame: 24 hours
Concentration of serum lactate in serum.
Lactate level measured in maternal serum.
Time frame: 0 hours
Concentration of beta-hydroxy-butiric acid in serum.
Beta-hydroxy-butiric acid level measured in maternal serum.
Time frame: 0 hours
Insulin resistance factor (HOMA-IR).
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Insulin resistance measured in maternal serum.
Time frame: 0 hours
Concentration of isoprostane in urine.
Isoprostane level measured in maternal urine.
Time frame: 0 hours