Laser Therapy on Orthodontic Tooth Movement

Ildeu Andrade Jr.24 enrolled

Overview

The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Laser Therapy Orthodontic Tooth Movement Bone Remodeling

Interventions

Low-level Laser TherapyDEVICE

Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons

Orthodontic forcePROCEDURE

Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement

Eligibility

Sex: ALLMin age: 13 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Facial convexity * Protrusion or biprotrusion of the incisors * Dental crowding * Healthy periodontal condition * Satisfactory oral hygiene Exclusion Criteria: * Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months * Skeletal crossbite * Parafunctional habits * Occlusal interference

Locations (1)

Pontifical Catholic University of Minas Gerais

Belo Horizonte, Minas Gerais, Brazil

Outcomes

Primary Outcomes

Rate of orthodontic tooth movement, with and without low-level laser therapy

The canine retraction was measured with a digital dynamometer

Time frame: The quantification of OTM was performed before canine retraction

Rate of orthodontic tooth movement, with and without low-level laser therapy

The canine retraction was measured with a digital dynamometer

Time frame: The quantification of OTM was performed after 1 month of canine retraction

Rate of orthodontic tooth movement, with and without low-level laser therapy

The canine retraction was measured with a digital dynamometer

Time frame: The quantification of OTM was performed after 2 months of canine retraction

Rate of orthodontic tooth movement, with and without low-level laser therapy

The canine retraction was measured with a digital dynamometer

Time frame: The quantification of OTM was performed after 3 months of canine retraction

Secondary Outcomes

Chemokine levels in the periodontal tissue after LLLT and orthodontic force

The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)

Time frame: The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy

Data from ClinicalTrials.gov

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