Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy

Institute of Dental Sciences, Bareilly, Uttar Pradesh, India120 enrolled

Overview

Clinical evaluation of local subgingival application of injectable platelet-rich fibrin ( i-PRF ) for chronic periodntitis as adjunctive to non surgical therapy and compare it with hyaluronic acid. 120 periodontal patients will receive a scaling and root planing ( non surgical periodontal therapy). Equal number of patients will receive subgingival application of i-PRF, hyaluronic acid or placebo gel as the adjunction to non surgical therapy.

The aim of the study is to evaluate and compare the clinical efficacy of subgingival application of i-PRF and hyaluronic acid gel as adjunctive to non-surgical periodontal therapy. 120 periodontal patients will receive traditional mechanical supra and subgingival scaling and root planing. Patients were randomly allocated in three groups. Group 1, 2 and 3 will receive subginigval application of placebo, hyaluronic acid gel and i prf respectively. Clinical parameters will be evaluated: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival recession (GR). Clinical measurements will be performed at baseline, 1 month and at 3 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

120

Conditions

CHRONIC PERIODONTITIS

Interventions

Placebo gelOTHER

Localized subgingival application

Hyaluronic acid gelDRUG

Localized subgingival application

Platelet rich fibrinBIOLOGICAL

Localized subgingival application

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients are in general good health. * Patients having minimum of 20 permanent teeth. * They have not taken medication known to interfere with periodontal tissue health or healing in the preceding 6 months. * Presence of periodontal pockets (≥5 mm) and clinicala ttachment level \> 5 mm. Exclusion Criteria: * Immunosuppressive systemic diseases (like cancer, AIDS, diabetes etc.) * Clotting and Hematological disorders * Patients with grade III mobility. * Patients with smoking and alcohol consuming habit. * Pregnant and lactating female. * Medications influence on the gingival and periodontal tissues (like calcium channel blockers, or Long-term steroid use) * The teeth with poor filling and ill fitted restorations

Outcomes

Primary Outcomes

Clinical attachment level (CAL)

Measure as the change in distance from the cementoenamel junction to the bottom of the gingival sulcus by using a periodontal probe (UNC 15 "University of North Carolina")

Time frame: 3 Months

Secondary Outcomes

Probing pocket depth

Measure as the change in distance from the gingival margin GM to the bottom of the gingival sulcus by using a periodontal probe (UNC 15 "University of North Carolina")

Time frame: 3 Months

Data from ClinicalTrials.gov

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