Using Sensors to Measure Drug Concentrations in Exhaled Breath

Nadav Goldental100 enrolled

Overview

The use of blood tests to measure drug concentrations in psychiatric patients is often a crucial part of monitoring and evaluating the course of treatment. Such tests are commonly conducted as part of official protocols, and patients are often tested on a weekly basis. The current study aims to examine the possibility of using a novel, non-invasive device to measure drug concentrations in exhaled breath as an alternative to blood tests. The device, SniffPhone, uses sensors to detect and measure volatile organic compounds (VOCs) in exhaled breath, and features a small and portable design. Sniff Phone has been previously approved for use in clinical trials and has been used successfully to screen for particular types of cancer and other diseases.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Mental Disorder

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Proper ability to give informed consent * Psychiatric patients undergoing treatment at Sheba Medical Center * Patients with treatment plans that require therapeutic drug monitoring Exclusion Criteria: * Involuntary psychiatric hospitalization * Pregnancy

Outcomes

Primary Outcomes

Detection of drug type and concentration in volatile organic compounds (VOCs) profile

Detection of drug type and concentration in VOCs profile (measured using Sniff Phone)

Correlation between drug concentration and volatile organic compounds VOC concentrations

Correlation between drug concentration (as measured in blood test) and VOCs (hexanone acetic acid, heptane, hexanal, 3-heptanone, hexanoic acid, heptanal and nonanal) measured using Sniff Phone.

Time frame: Up to 6 months