Based on the previous symptomatic treatment of Chinese HD patients, this study intends to further optimize the treatment regimen of Chinese HD patients so as to further improve the prognosis of patients.
The purpose of the study is to evaluate symptomatic treatment regimen efficacy based on different disease stages. We previously used symptomatic treatment on Chinese HD patients and most of them got improved both in the motor symptoms and life quality. So this study intends to further optimize the treatment regimen, and set a control group to further evaluate the treatment efficacy.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Haloperidol take 0.5mg\~2mg three time a day.
Risperidone take 1mg once at night.
Zoloft take 50mg once in the morning.
Second Affiliated Hospital,Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
RECRUITINGThe Unified Huntington's Disease Rating Scale
The Unified Huntington's Disease Rating Scale consist of four subscales, including motor(0-124), MMSE (0-30), psychiatric (0-176), and functional domains(1-13). Four subscale scores are summed to compute a total score. Higher motor and psychiatric scores represent worse outcomes but higher MMSE score and functional scores indicate good outcome.
Time frame: Five years
Brain MRI
Brain MRI is used to assess the atrophy of caudate nucleus and cortex in HD patients
Time frame: Five years
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Idebebone take 30mg three times a day.
The recommended starting dose of Austedo is 6 mg administered orally once daily, and dose may be increased at weekly intervals in increments of 6 mg per day to a maximum recommended daily dosage of 48 mg.