This small, randomized, double blind, placebo controlled pilot study is aimed at determining the effects of oral Immulina dietary supplementation on specific immune biomarkers in the blood.
This small, randomized, double blind, placebo controlled pilot study is aimed at determining the effects of four weeks of daily Immulina dietary supplementation (800 mg/day) versus four weeks of daily placebo on natural killer (NK) cell numbers and/or natural killer (NK) cell activity in human peripheral blood mononuclear cells collected from human research participants who meet the trial's inclusion/exclusion criteria.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
40
Immulina Dietary Supplementation is a highly standardized extract derived from various preparations of Spirulina, a cyanobacterium, marketed as a dietary supplement and has been utilized in several clinical studies describing its immunopotentiating properties.
University of Mississippi Medical Center
Jackson, Mississippi, United States
Natural Killer (NK) cell count
Differences in NK cell counts from baseline to 4 weeks
Time frame: 4 weeks
Natural Killer (NK) cell cytotoxic activity
Differences in NK cell cytotoxic activity from baseline to 4 weeks
Time frame: 4 weeks
Cytokine profiles
Differences in in-Vitro peripheral blood mononuclear cell (PBMC) culture supernatants' cytokine profiles from baseline to 4 weeks (IFN-α, IFN-γ, IL-1β, IL-2, IL-4, IL-6, Il-10, IL-12, Il-15 and TNFα)
Time frame: 4 weeks
Immune cell populations
Differences in immune cell populations in PBMC from baseline to 4 weeks.
Time frame: 4 weeks
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