FIrst-Pass Reperfusion With the NeVa Stent-Retriever Trial

Inclusion Criteria: * Age ≥ 18 years * A new focal disabling neurologic deficit consistent with acute cerebral ischemia * NIHSS score ≥ 6; * Prestroke mRS score of ≤ 2; * Angiographic confirmation by DSA of an occlusion (eTICI 0-1) of the intracranial ICA, MCA-M1, MCA-M2, basilar artery, or intracranial vertebral artery with or without tandem involvement of the cervical ICA or cervical vertebral artery; * Imaging Criteria: 1. Strokes in the Anterior Circulation: * Non-Contrast CT (NCCT): ASPECTS 6 to 10 on baseline CT, or * CT perfusion (with Automated Volume Calculation): core infarct volume ≤ 70cc and Mismatch Ratio ≥ 1.5 * CT perfusion (without Automated Volume Calculation): ASPECTS 6 to 10 on the CBV maps with Visualized MTT or TMax - CBV Mismatch greater than 50%, or * Brain MRI: ASPECTS 6 to 10 (and \<70cc if Automated Volume Calculation is available) on baseline diffusion-weighted sequence (DWI). 2. Strokes in the Posterior Circulation: pc-ASPECTS score 8 to 10 on baseline NCCT, CTA-source images, or DWI MRI. * Subjects for whom IV-tPA is indicated and who are available for treatment, are treated with IV-tPA within 4.5 hours of stroke onset (onset time is defined as the last time when the subject was witnessed to be at baseline), with verification that the subject has received/is receiving the correct IV t-PA dose for the estimated weight * Arterial puncture within 12 hours of symptom onset (or time last seen well - TLSW), thrombectomy procedure able to be completed within 2 hours from procedure start (arterial puncture). * Subject or legal representative is able and willing to give informed consent. Exclusion Criteria: * Rapid neurological improvement prior to groin puncture suggestive of resolution of stroke * Seizures at stroke onset if it makes the diagnosis of stroke doubtful and precludes obtaining an accurate baseline NIHSS assessment. * Note: Subjects with a questionable seizure at onset of stroke should not be excluded if DSA confirms the presence of intracranial ICA and/or M1 occlusion, and accurate NIHSS can be obtained. * Pre-existing medical neurological or psychiatric disease that would confound the neurological or functional evaluations, e.g. dementia with prescribed anti-cholinesterase inhibitor (e.g. Aricept). * Cardiopulmonary resuscitation, significant cardiac arrhythmia, evidence of ongoing myocardial infarction, concern for pre-treatment pulmonary aspiration. * Clinical symptoms suggestive of bilateral stroke or stroke in multiple territories. * Cerebral vasculitis. * History of severe allergy to contrast medium. * Known allergy to stent retriever materials (nitinol, stainless steel); * Suspicion of aortic dissection, septic embolus, or bacterial endocarditis. * Active infection. * Baseline CT or MRI showing mass effect or intracranial tumor (except small meningioma \[≤ 3 cm\]). * CT or MRI evidence of recent/fresh hemorrhage on presentation. * CTA, MRA, or DSA evidence of flow limiting carotid dissection, high-grade stenosis, or complete cervical carotid occlusion requiring stenting at the time of the index procedure (i.e., mechanical thrombectomy). * Evidence of dissection in the intracranial cerebral arteries; * Uncontrolled hypertension on presentation (defined as SBP \> 220 mmHg and / or DBP \> 120 mmHg). For subjects placed on intravenous BP medication, uncontrolled hypertension is defined as SBP \> 185 mmHg and / or DBP \> 110 mmHg. * Baseline hemoglobin of \< 7 mmol/L. * Baseline platelet count \< 50,000/uL. * Renal failure as defined by a serum creatinine \>3.0 mg/dL (264 mmol/L). * Note: subjects on renal dialysis may be treated regardless of serum creatinine levels. * Known hemorrhagic diathesis, coagulation factor deficiency, or on anticoagulant therapy with INR \> 3.0 or PTT \> 3 times normal. Subjects on factor Xa inhibitor for 24-48 h ago must have a normal PTT. * Baseline blood glucose of \< 50 mg/dL (2.78 mmol) or \> 400 mg/dL (22.20 mmol). Note: The ''correction'' of baseline glucose or coagulation laboratory values to meet inclusion criteria will not be allowed. * Females who are pregnant or breastfeeding. * Known current or recent use of illicit drugs or alcohol abuse. * Use of an investigational drug or device within past 3 months; * Life expectancy less than 6 months. * Any other condition that, in the opinion of the investigator, precludes an endovascular procedure or poses a significant hazard to the subject if an endovascular procedure was performed.