In this study, the investigators detected the expression of SREBP1 in thyroid cancer tissues, explored the biological functions of SREBP1 in thyroid cancer cells.
qRT-PCR and immunohistochemistry were used to detect the expression of SREBP1 in 96 pairs thyroid cancer tissues and the adjacent normal tissues. The following methods, including the MTS, colony-forming assay, flow cytometry and hoechst staining were used to detect the biological function of thyroid cancer cells based on SREBP1 interference or not.
Study Type
OBSERVATIONAL
Enrollment
140
All the enrolled patients were treated with whole resection and diagnosed by the Pathology Department based on the pathological evidence.
the Affiliated Cancer Hospital of Xiangya Medical School
Changsha, Hunan, China
progression-free survival
disease recurrent of progression
Time frame: average 5 years
theraputic efficacy
According to the ATA guideline, patients were divided into four group, including excellent response (ER),indeterminate response (IDR), biochemical incomplete response (BIR), structural incomplete response (SIR) after surgery and radioiodine treatment.
Time frame: average 18 months
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