The purpose of this protocol is to define an "individualized diet" approach based on obesity related phenotypes (pathophysiology obesity classification), which would increase weight loss, adherence, and weight loss maintenance.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
215
Research team will prescribe diet, exercise, behavioral plan for the participant to follow for the 12 week study. The lifestyle plan will be based on the Mayo Clinic Diet program.
Research team will prescribe diet, exercise, behavioral plan for the participant to follow for the 12 week study. The lifestyle plan will be based on the participants obesity phenotype.
Mayo Clinic
Rochester, Minnesota, United States
12-week total body weight loss
Change in body weight during the 12 week study
Time frame: 12 weeks
Responder Rate
Proportion of patients losing \> 3% of total body weight
Time frame: 12 weeks
Waist Circumference
Change in waist circumference (cm)
Time frame: 12 weeks
Fat Loss
Change in fat mass during the 12 week study using DEXA
Time frame: 12 weeks
Calorie Intake
Change in daily calorie intake
Time frame: 12 weeks
Calories to Fullness
Change in calories consumed to fullness during the 12 week study using satiation test
Time frame: 12 weeks
Gastric Emptying
Change in half gastric emptying time during the 12 week study using scintigraphy
Time frame: 12 weeks
Gastric Emptying 2 Hours
Change in gastric emptying percentage at 2 hours during the 12 week study using scintigraphy
Time frame: 12 weeks
Anxiety Level
Change is anxiety level during the 12 week study using the HADS-A scale
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Time frame: 12 weeks
Emotional Eating
Change is emotional eating level during the 12 week study using the TFEQ score
Time frame: 12 weeks
Resting Metabolic Rate
Change in resting energy expenditure during the 12 week study using an indirect calorimetry
Time frame: 12 weeks
Adherence
Adherence and compliance with program defined by the number of contacts with the team
Time frame: 12 weeks