Nowadays, general anaesthesia is carried under "balanced anesthesia technique" in which many anesthetic adjuvants are used simultaneously, including opioid analgesics in order to reduce the amount of inhalation agents. The most popular adjuvants used are remifentanil, which is an opioid analgesic, and dexmedetomidine. Both of these agents are short acting, can be infused with targeted concentrations, excreted shortly from the body with stable hemodynamics. Remifentanil, when infused for more than 2 hours, causes hyperalgesia to increase the amount of pain postoperatively as well as the amount of opioid analgesics. However, dexmedetomidine does not cause hyperalgesia and is known to have an opioid -sparing effect. In our center. In this study, we aim to compare the effects of remifentanil and dexmedetomidine on postoperative pain in patients undergoing Nuss procedure, which is a very painful operation on the chest wall.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
62
Comparing effects of remifentanil versus dexmedetomidine
Jung Min Koo
Seoul, South Korea
Visual Analogue Scale
Pain scale ranges from 0 to 10. 0 means no pain at all, and 10 being the most severe pain anyone can imagine.
Time frame: Between 1~6 hours postoperatively.
Visual Analogue Scale
Pain scale ranges from 0 to 10. 0 means no pain at all, and 10 being the most severe pain anyone can imagine.
Time frame: Between 6~12 hours postoperatively.
Visual Analogue Scale
Pain scale ranges from 0 to 10. 0 means no pain at all, and 10 being the most severe pain anyone can imagine.
Time frame: Between 12~24 hours postoperatively.
Visual Analogue Scale
Pain scale ranges from 0 to 10. 0 means no pain at all, and 10 being the most severe pain anyone can imagine.
Time frame: Between 24~48 hours postoperatively.
Amount of postoperative intravenous patient controlled analgesics (PCA) used
Time frame: At 60 minutes after the end of surgery
Amount of fentanyl used postoperatively at the recovery unit
Amount in micgrograms per wegith in kilograms (migrogram/kilogram)
Time frame: At 60 minutes after the end of surgery
Time needed for postoperative rescue opioid analgesics
Time frame: At 60 minutes after the end of surgery
Amount of remifentanil or dexmedetomidine used intraoperatively
Time frame: Immediately at the end of the surgery
Intraoperative hemodynamic change: Systolic blood pressure
Time frame: 1 minute after monitoring (of blood pressure, heart rate, pulse oxymeter and electrocardiogram) starts, when the patient arrives at the operating room
Intraoperative hemodynamic change: Diastolic blood pressure
Time frame: 1 minute after monitoring (of blood pressure, heart rate, pulse oxymeter and electrocardiogram) starts, when the patient arrives at the operating room
Intraoperative hemodynamic change: mean blood pressure
Time frame: 1 minute after monitoring (of blood pressure, heart rate, pulse oxymeter and electrocardiogram) starts, when the patient arrives at the operating room
Intraoperative hemodynamic change: heart rate
Time frame: 30 minutes after the induction of anesthesia
Intraoperative hemodynamic change: mean blood pressure
Time frame: At the end of the surgery, average of 90minutes after the induction of anesthesia
Intraoperative hemodynamic change: heart rate
Time frame: At the end of the surgery, average of 90minutes after the induction of anesthesia
Intraoperative hemodynamic change: Systolic blood pressure
Time frame: At the end of the surgery, average of 90minutes after the induction of anesthesia
Intraoperative hemodynamic change: Diastolic blood pressure
Time frame: At the end of the surgery, average of 90minutes after the induction of anesthesia
Rescue drugs (inotropics or vasopressors) used in order to correct hypotension or bradycardia
Time frame: Intraoperatively
Postoperative complications
Number of events that happened to the patient: e.g. Yes or No, and how many times. Nausea/vomiting, hypotension, respiratory depression, urinary retension, dizziness, transient cease in use of intravenous patient controlled analgesics (PCA)
Time frame: Between 1~6 hours postoperatively
Postoperative complications
Number of events that happened to the patient: e.g. Yes or No, and how many times. Nausea/vomiting, hypotension, respiratory depression, urinary retension, dizziness, transient cease in use of intravenous patient controlled analgesics (PCA)
Time frame: Between 12~24 hours postoperatively
Postoperative complications
Number of events that happened to the patient: e.g. Yes or No, and how many times. Nausea/vomiting, hypotension, respiratory depression, urinary retension, dizziness, transient cease in use of intravenous patient controlled analgesics (PCA)
Time frame: Between 24~48 hours postoperatively
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