Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease

Peking University First Hospital300 enrolled

Overview

Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD). Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.

Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Lean Body Mass Chronic Kidney Diseases

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * non-dialyzed patients with CKD stage 3-5 * clinical stable * a willingness to be examined with all measurements being taken simultaneously. Exclusion Criteria: * systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor * severe edema within one month prior to the study * chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy, * taking immunosuppressive agents and anti-inflammatory medication chronically

Locations (1)

Renal Division and Institute of Nephrology, Peking University First Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

LBM_DEXA

lean body mass measured by dual-energy x-ray absorptiometry (DEXA)

Time frame: between March 1st, 2014 and December 1st, 2015

Data from ClinicalTrials.gov

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