Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC

Inclusion Criteria: * Age ≥13 and \<51 years old at time of enrollment; * No prior history of concussion or TBI in the last 6 months. For head injured subjects * Having sustained a traumatic closed head injury within 120 hours (5 days from time of injury at time of BrainScope assessment); * GCS 13-15 at time of BrainScope assessment. For non-concussed head-injured controls * Having sustained a traumatic closed head injury but returned to play or deemed non-concussed following sideline (on-field) evaluation within the same game and enrolled in the study within 120 hours (5 days) from said incident. * GCS 13-15 at time of BrainScope assessment. For matched controls and healthy volunteers • GCS 15 at time of BrainScope assessment. Exclusion Criteria: * Enrolled in any previous BrainScope clinical study; * Current CNS active prescription medications taken daily, except for medication being taken for the treatment of Attention Deficit Disorders (ADD/ADHD); medication for smoking cessation; or medications for anxiety taken PRN (as needed); * Forehead, scalp or skull abnormalities that prevents headset application for EEG data collection in injured/matched controls; * History of brain tumor, brain surgery or known neurological disease including, Parkinson's, MS, Alzheimer's, dementia, epilepsy; * History of TIA or Stroke within the last year; * Pregnant women; * Subjects who do not speak English (non-English speaking parents are allowed to consent so long as translation of the consent form in their native language is available); * Acute intoxication ; * Evidence of illicit drug abuse in the last year; * Active fever defined as greater than 100ºF or 37.78ºC at time of BrainScope assessment; * Subjects currently receiving dialysis or have end-stage renal disease; * Subjects requiring advanced airway management (i.e. mechanical ventilation); * Prisoners. For head injured subjects * Loss of consciousness ≥ 20 minutes related to the concussion injury; * Evidence of abnormality visible on Computerized Tomography (CT) of the head related to the traumatic event (note: neuroimaging is not required for enrollment); * For current injury, hospital admission (other than the Observation Unit) ranging more than 24 hours due to either head injury or collateral injuries. For non-concussed head-injured controls * Loss of consciousness ≥ 20 minutes related to the head impact; * Any focal neurological signs including aphasia, apraxia, diplopia, facial droop, dysarthria/slurred speech; * Any score \>3 on a 7-point Likert scale (0=none, 6=severe) for the following symptoms at the time of BrainScope assessment (compared to how the subject normally feels): headache, dizziness, balance problems, neck pain, feeling slowed down; For matched controls and healthy volunteers * Any focal neurological signs including aphasia, apraxia, diplopia, facial droop, dysarthria/slurred speech; * Hospital admission (other than the Observation Unit) ranging more than 24 hours due to either head injury or collateral injuries in the past 6 months; * Any score \>3 on a 7-point Likert scale (0=none, 6=severe) for the following symptoms at the time of BrainScope assessment (compared to how the subject normally feels): headache, dizziness, balance problems, neck pain, feeling slowed down. For healthy volunteers * Legally blind in one or both eyes; * History of eye surgery in the past year; * Any known eye disorders including age-related macular degeneration (AMD), glaucoma, lazy eye, diplopia, cataracts, etc.