The aim of the current study is to evaluate the safety and efficacy of Montelukast in treatment of obese patients with type 2 diabetes (T2DM).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
Montelukast is an orally dosed drug (available as a chewable tablet) which is FDA-approved for the treatment of chronic asthma and prophylaxis and the prevention of exercise-induced bronchoconstriction. It is also approved for the relief of symptoms of both seasonal and perennial allergic rhinitis.
Placebo tablet once daily
Faculty of Medicine
Shebin Elkom, Egypt
Change in HbA1c
HbA1c
Time frame: From baseline to 12 weeks
Percent change in body weight
Body Weight
Time frame: From baseline to 12 weeks
BMI
body mass index
Time frame: From baseline to 12 weeks
Visceral Adiposity Index
visceral fat
Time frame: From baseline to 12 weeks
Adiponectin
Serum level of adiponectin
Time frame: At baseline to 12 weeks
TNF-α
Serum level of Tumor necrosis factor alpha (TNF-α)
Time frame: At baseline to 12 weeks
IL-6
Serum level of interleukin-6 (IL-6)
Time frame: At baseline to 12 weeks
leukotriene B4
Serum level of leukotriene B4 (LTB4)
Time frame: At baseline to 12 weeks
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