A Trial of Transplanting Hepatitis C Kidneys Into Hepatitis C-Negative Kidney Recipients

Inclusion Criteria: * Able to provide informed consent * Active waiting list status for isolated kidney transplant * 18 years of age or older * No living kidney donor * Panel reactive antibody (PRA) ≤97% (most recent cPRA at time of screening). Patients with a PRA of 98-100% at screening can be included unless patient has a most recent cytotoxic PRA of \>25% or calculated PRA \>50% where multiple moderate level HLA antibodies exist and in the opinion of the local site investigator represents substantial HLA sensitization. If patient has a PRA of 98-100%, the donor-recipient pair must meet additional eligibility criteria. Exclusion Criteria: * Hepatocellular carcinoma * Hepatitis B surface antigen and/or DNA positive * Active Hepatitis C infection * HIV RNA-positive or HIV antibody positive * Other chronic liver disease (excluding non-alcoholic fatty liver disease \[NAFLD\] with normal liver enzymes) * Persistently elevated liver transaminases (defined as the upper limit of normal at the reference laboratory) * Advanced hepatic fibrosis or cirrhosis * Primary Focal Segmental Glomerulosclerosis (FSGS), FSGS recurring in initial transplant, or other disease process at high risk of early graft failure per the treating transplant nephrologist * Current use of amiodarone or dronedarone (due to interaction with sofosbuvir) * Transplant candidate requires antibody desensitization protocol for transplantation * Female who is pregnant, planning to become pregnant during the study, or breast-feeding * Participation in another interventional study, from a period starting 6 months prior to screening to last study visit, that the study PIs judge would interfere with either the aims or the safety of the THINKER-NEXT study.