In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with grown-up congenital heart disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
7
Oxygen application Supplemental oxygen via mask
Room air applied via mask
University Hospital Zurich, Division of Pneumology
Zurich, Switzerland
Work Rate (Watt)
Maximal Work Rate (Wmax) measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Endurance Time (s) Endurance Time (s) Endurance Time (s)
Endurance (s) with 75% Wmax measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Peak Oxygen uptake
measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Respiratory Exchange ratio
measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Changes in arterial blood parameters
measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
muscle tissue oxygen
Oxygen saturation in the muscle measured during cardiopulmonary exercise test oxygen vs. room air with near infrared spectroscopy
Time frame: 1 day
cerebral tissue oxygen
Oxygen saturation in the brain measured during cardiopulmonary exercise test oxygen vs. room air with near infrared spectroscopy
Time frame: 1 day
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