Previous studies have indicated increased vasopressin due to hypertonic saline infusion impairs glucose regulation. The current study will examine the effect of low water intake on glucose regulation. No currently published study has investigated the acute effect of low water intake on glucose regulation using continuous glucose monitoring over the course of a full day. The aim of the study is to observe the effect of low water intake on glucose regulation in low drinkers. The study will study the glycemic responses to standardized meals in adults during an 11-hour period in two conditions: a) high water intake and b) low water intake. It is hypothesized that the area under the glucose curve will be greater in the low water intake trial as compared to the high water intake trial
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
7
Increased water intake during the 11 h protocol
Arizona Biomedical Collaborative
Phoenix, Arizona, United States
Area under the curve of Glucose at lunch
Time frame: 2-hour window starting right before the lunch meal (12:00 pm - 2:00 pm)
Area under the curve of Glucose at Dinner
Time frame: 2-hour window starting right before dinner (4:00 pm - 6:00 pm)
Area under the curve of Glucose for the entire experiment
Time frame: 11-hour window starting right before breakfast till 2 hours after dinner (7:00 am - 6:00 pm)
Area under the curve of Copeptin for the entire experiment
Time frame: 11-hour window starting right before breakfast till 2 hours after dinner (7:00 am - 6:00 pm)
Area under the curve of Glucagon at lunch
Time frame: 2-hour window starting right before the lunch meal (12:00 pm - 2:00 pm)
Area under the curve of Glucagon at dinner
Time frame: 2-hour window starting right before dinner (4:00 pm - 6:00 pm)
Urinary glucose excretion
Time frame: Entire 11-hour protocol 7:00 am - 6:00 pm
Area Under the Curve for Plasma osmolality
Time frame: the entire 11-hour protocol 7:00 am - 6:00 pm
Area under the curve of Insulin at lunch
Time frame: 2-hour window starting right before the lunch meal (12:00 pm - 2:00 pm)
Area under the curve of Insulin at dinner
Time frame: 2-hour window starting right before dinner (4:00 pm - 6:00 pm)
Area under the curve of Glucagon like peptide 1 at dinner
Time frame: 2-hour window starting right before dinner (4:00 pm - 6:00 pm)
Area under the curve of Glucagon like peptide 1at lunch
Time frame: 2-hour window starting right before the lunch meal (12:00 pm - 2:00 pm)
Area under the curve of plasma cortisol
Time frame: the entire 11-hour protocol 7:00 am - 6:00 pm
Area under the curve for Thirst rating
Thirst assessed by Visual analog scale
Time frame: the entire 11-hour protocol 7:00 am - 6:00 pm
Mood assessment with a questionnaire
Assessed by Profile of mood state questionnaire
Time frame: single measurement at baseline before the beginning of breakfast at 7:00 am and 1-hour before dinner meal at 3:00 pm
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