To study the effects of age on the immune system's response to flu vaccine and to study the connection between the immune system and physical and cognitive changes associated with aging.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
10
Seasonal influenza vaccination with FDA approved vaccines for this age group.
Adjuvanted (MF59) inactivated influenza vaccine
Recombinant hemagglutinin vaccine
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Hemagglutinin Antigen Inhibition Assay Titers at Baseline
2 fold dilution series of serum, and measurement of titer which inhibits hemagglutination. Titers were measured for each of 4 antigens in the vaccine (A/Brisbane/2018 (H1N1), A/Kansas/2017 (H3N2), B/Colorado/2017 (Vic), B/Phuket/2013 (Yam))
Time frame: Baseline Baseline
Hemagglutinin Antigen Inhibition Assay Titers at Day 28
2 fold dilution series of serum, and measurement of titer which inhibits hemagglutination. Titers were measured for each of 4 antigens in the vaccine (A/Brisbane/2018 (H1N1), A/Kansas/2017 (H3N2), B/Colorado/2017 (Vic), B/Phuket/2013 (Yam))
Time frame: Day 28 Baseline
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