Intrahepatic cholangiocarcinoma (ICC) is one of the common malignant tumors. Lymph node metastasis is an important factor affecting the poor prognosis of intrahepatic cholangiocarcinoma. The eighth edition of the AJCC guidelines recommends at least 6 lymph nodes to be used for staging. The American Hepatobiliary and Pancreatic Association also recommends the removal of hilar lymph nodes as part of the radical surgery for intrahepatic cholangiocarcinoma. However, some scholars have found that patients with regional lymph nodes have similar survival rates. This contradictory result has prompted more scholars to conduct clinical research to explore the necessity and standardization of lymph node dissection in intrahepatic cholangiocarcinoma.
Expanding lymph node dissection can theoretically obtain more lymph node dissection. Obtaining enough lymph nodes can improve the accuracy of AJCC staging and accurately determine prognosis. However, it is unclear whether it will improve the prognosis of patients with lymph node dissection. According to literature reports and related studies, expanded lymph node dissection for right liver tumors included stations 12, 8, and 13, and left lymphoma expanded lymph node dissection includedstations 12, 1, 3, 7, and 8. In summary, standardize the extent of lymph node dissection in intrahepatic cholangiocarcinoma, and obtain enough lymph node dissection under the premise of controlling the complication rate, which is helpful for accurate TNM staging, accurate judgment of prognosis and improvement of survival time. Improve prognosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
168
Expanded lymph node dissection for right liver tumors included stations 12, 8, and 13, and stations 12, 1, 3, 7, and 8 for left liver tumors
The Johns Hopkins Hospital
Baltimore, Maryland, United States
RECRUITINGChina-Japan Friendship Hospital
Beijing, Beijing Municipality, China
RECRUITINGChinese PLA General Hospital
Beijing, Beijing Municipality, China
RECRUITINGSun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China
RECRUITINGHunan Provincial People's Hospital
Changsha, Hunan, China
RECRUITINGThe Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China
RECRUITINGRenji Hospital Affiliated to Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China
RECRUITINGXinhua Hospital Affiliated to Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China
RECRUITINGZhong Shan Hospital Fudan University
Shanghai, Shanghai Municipality, China
RECRUITINGThe First Affiliated Hospital of Xi 'an Jiaotong University
Xi’an, Shanxi, China
RECRUITING...and 3 more locations
Disease free survival (DFS)
disease free survival
Time frame: 5 years after surgery
3-year Overall survival (OS)
3-year overall survival
Time frame: 3 years after surgery
Rate of Postoperative Complications (PC)
Postoperative Complications
Time frame: From the date of surgery to stitches off (up to 2 month)
5-year Overall survival (OS)
5-year Overall survival
Time frame: 5 years after surgery
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