Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
31
Participants will consume a meal containing a stable iron isotope following exercise or rest.
Florida State University
Tallahassee, Florida, United States
Change in fractional iron absorption
Stable iron isotopes
Time frame: Red blood cells collected on day 0 and day 14
Change in concentration of ferritin in ng/mL
Blood measure
Time frame: Day 0 and day 14
Change in concentration of soluble transferrin receptor in nmol/L
Blood measure
Time frame: Day 0 and day 14
Change in concentration of hemoglobin in g/L
Blood measure
Time frame: Day 0 and day 14
Change in concentration of hematocrit as %
Blood measure
Time frame: Day 0 and day 14
Change in concentration of hepcidin in ng/mL
Blood measure
Time frame: Day 0 and day 14
Change in concentration of IL-6 in pg/mL
Blood measure
Time frame: Day 0 and day 14
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